Analysis of the incidence and mortality rate of Alzheimer's and other dementias during the last 30 years in Iran

Introduction: Assessing the course of Alzheimer's disease and other dementias is very important due to lack of a definitive treatment, increase in life expectancy, and aging population. This study aimed to investigate the long-term trend in the incidence and mortality rate of Alzheimer's and other dementias in Iran during 1990-2019. Materials and Methods: Age-Standardized Incidence Rate (ASIR) and Age-Standardized Mortality Rate (ASMR) of Alzheimer's and other dementias was collected by sex, and incidence and mortality rates of Iran for each 5 yeas group was extracted from the Global Burden of Disease site. ASIR and ASMR trends were analyzed using the Joinpoint Regression model. Results: In this study, the trend of standardized incidence of age-related Alzheimer's and other dementias increased significantly by an yearly average of 0.02% for 30 years, and for the mortality rate, 0.004% annual insignificant decrease was observed. The trend in the standardized incidence and mortality of Alzheimer's and other dementias during the study period was declining for men but upward for women. The highest average annual percent change (AAPC) for incidence and mortality of Alzheimer's and other dementias was observed in the age group of 50-54 years with AAPC= 0.19, and 75-79 years with AAPC= 0.11 respectively. Conclusion: The results of study showed that in Iran the ASIR, and ASMR of Alzheimer's and other dementias is decreasing in male and increasing in femals, and also its rate is more in the area.  Therefore, informative action, and more serious preventive steps should be taken, especially for women and in the age group of 50-54 years.